Lamp2 lamp2a

Author: kgxm

August undefined, 2024

TīmeklisLAMP1 (lysosomal-associated membrane protein 1) and LAMP2 are the most abundant protein components of lysosome membranes. Both LAMPs have common structures consisting of a large lumenal domain composed of two domains (N-domain and C-domain, which are membrane-distal and -proximal, respectively), both with the β … Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process that is dependent on the membrane protein LAMP2A. Moreover, we demonstrate that this mechanism is independent of the ESCRT machinery but dependent on HSC70, …

LUXA2

TīmeklisLysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) are two abundant lysosomal membrane proteins (1,2). Both are transmembrane proteins and are heavily glycosylated at the amino … Tīmeklis2024. gada 12. nov. · Abstract. Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the chaperone-mediated autophagy (CMA) pathway. … freedom bank john rich

Inhibition of JNK increases the sensitivity of hepatocellular

TīmeklisIsoform LAMP-2C Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of … TīmeklisIn this work, we identified and validated 2 NFE2L2 binding sequences in the LAMP2 gene and demonstrated in several human and mouse cell types that NFE2L2 deficiency and overexpression was linked to reduced and increased LAMP2A levels, respectively. Accordingly, lysosomal LAMP2A levels were drastically reduced in nfe2l2-knockout … Tīmeklis2024. gada 28. marts · 在这项研究中，研究人员发现含有与KFERQ基序相关的氨基酸序列的蛋白质被包装到外泌体的亚群中。研究人员确定以下几种蛋白是该机制的基本组成部分：溶酶体相关膜蛋白2的同工型A (LAMP2A)，此前被认为是一种将含有KFERQ的底物靶向溶酶体的蛋白质；以及分子伴侣热休克蛋白HSC70。此外，研究人员证明蛋白 … freedom bank of rockport

Tumor cells induce LAMP2a expression in tumor-associated

Phosphorylation of LAMP2A by p38 MAPK couples ER stress to

TīmeklisThe LAMP2 gene provides instructions for making a protein called lysosomal associated membrane protein-2 (LAMP-2), which, as its name suggests, is found in the … TīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. bloodwitch vinylTīmeklis2024. gada 25. marts · LAMP2A originates from the alternative splicing of the LAMP2 gene, which contains nine exons, including three different splice variants of the exon 9 (A, B, and C) ( Fig. 1A ). All splice … blood witch dnd

"Tīmeklis2024. gada 8. febr. · LAMP2A decrease enhances the lysosomal damage induced by lysosomotropic agents, ultimately leading to cell death. The effect is cancer-specific, as JNK inhibition does not decrease LAMP2A in... " - Lamp2 lamp2a

Lamp2 lamp2a

LAMP-2 Antibody (H4B4) SCBT - Santa Cruz …

Tīmeklis2024. gada 27. sept. · LAMP-2 Antibody (H4B4) is an IgG 1 κ mouse monoclonal LAMP-2 antibody (also designated LAMP2 antibody, LAMPB antibody or lysosomal associated membrane protein 2 … Tīmeklis2024. gada 12. nov. · LAMP2A helps in lysosomal uptake of modified and oxidatively damaged proteins directly into the lumen of lysosomes for degradation and protein turnover. Elevated expression of LA … Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the chaperone-mediated autophagy (CMA) pathway.

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Tīmeklis2000. gada 15. dec. · Lamp2a acts as a receptor in the lysosomal membrane for substrate proteins of chaperone-mediated autophagy. Using antibodies specific for the cytosolic tail of lamp2a and others recognizing all lamp2 isoforms, we found that in rat liver lamp2a represents 25% of lamp2s in the lysosome. We show that lamp2a … TīmeklisSee all LAMP2A primary antibodies Description Rabbit monoclonal [EPR4207 (2)] to LAMP2A - Lysosome Marker Host species Rabbit Tested applications Suitable for: …

Tīmeklis2024. gada 21. marts · LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with LAMP2 include Danon Disease and Left … TīmeklisLAMPB; CD107b; LAMP-2; LGP110; LAMP2 Category Apoptosis Background Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. ... LAMP2a Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效 …

Tīmeklis从下图我们可以获知，微自噬和cma的共同点是需要hsc70这个伴侣蛋白的参与，且一般底物蛋白序列中有“kferq”基序。不同点在于，cma过程更复杂，且参与蛋白更多。其 … Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a …

TīmeklisCritically, Lamp2a is required for HCC xenograft growth in vivo by helping cells to avoid apoptosis and promoting cell proliferation. Furthermore, a significant correlation …

Tīmeklis2024. gada 18. marts · LAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study … blood witchesTīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate … freedom bank philippi wv hoursTīmeklisLAMP2A also prevented the progressive locomotor and oxidative defects induced by neuronal expression of PD-associated human SNCA (synuclein alpha) with alanine … bloodwitch pd2Tīmeklis兔多克隆抗体to LAMP2A - Lysosome Marker 宿主 Rabbit 经测试应用适用于: WB, ICC/IF, IHC-P more details 种属反应性与反应: Mouse, Human 预测可用于: Dog, … bloodwitch treeTīmeklisSynthetic peptide corresponding to Human LAMP2A aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. LAMP2 has 3 distinct isoforms, … bloodwitch gameTīmeklisLUXA2 believes that simplicity is the ultimate sophistication. Our design starts from a simple concept. freedom bank postville iowaTīmeklis2024. gada 24. nov. · Lysosomal p38 MAPK directly phosphorylates the CMA receptor LAMP2A at T211 and T213, which causes its membrane accumulation and active … blood witch