Webb1 mars 2011 · The translation initiation factor 4E (eIF4E) binds the 5′ m 7 GpppN cap structure (where N is any nucleotide) of mRNAs, delivering these mRNAs to the eIF4F complex. This complex, comprised of eIF4E, the ATP-dependent RNA helicase, eIF4A, and the scaffolding protein eIF4G, then scans through and unwinds the 5′untranslated … Webb1 mars 2011 · Signaling through the AKT-mTOR pathway activates eIF4E by phosphorylating the inhibitory 4E binding proteins (4E-BP). This liberates eIF4E and …
Dual mTOR/PI3K inhibitor NVP‑BEZ235 arrests colorectal cancer …
Webb8 sep. 2011 · First, loss of the full-length 4E-BP1 may impair energy homeostasis through dysregulation of translation initiation. 13 In addition, degradation of 4E-BP1 gives rise to a truncated 4E-BP1 peptide that binds to the strongly antiapoptotic protein eIF4E, thereby leading to potent inhibition of eIF4E. 14 Modulation of eIF4E activity may therefore be … Webb18 sep. 2024 · Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer. Author links open overlay panel Changlei Xi a 1, Ling Wang b 1, Jie Yu a, ... Moreover, inhibition of miR-338-3p in HT29 and HCT116 p53-/-cells increased their sensitivity to 5-FU treatment. capt dave\u0027s plano
Requirement for the eIF4E Binding Proteins for the …
WebbThe (2E,4E)-, (2Z,4Z)- (2E,4Z)- analogues were inactive, and 4,5-saturated and 4,5-alkynyl analogues also did not show inhibitory activity, demonstrating the importance of the (2Z,4E) diene unit. The aromatic ring was also crucial … Webb1 apr. 2024 · SIGNIFICANCE: These findings suggest that EIF4E-BP1 acts as a tumor suppressor in HNSCC and that 4E-BP1 dephosphorylation mediates the therapeutic response to mTORi, providing a mechanistic biomarker for future precision oncology trials. ©2024 American Association for Cancer Research. Publication types Research … Webb22 maj 2024 · Furthermore, when PP242 (1,000 nM) was used to treat the cells it was found to have a weak inhibitory effect on 4E-BP1 Thr37/46. However, at the same dose NVP-BEZ235 effectively inhibited 4E-BP1 phosphorylation (at Thr37/46). Conversely, we found that in SW480 cells, ... capt elvira obukhova