WebExamples of well-developed genetically engineered drug carriers include protein polymers composed from elastin-like polypeptides (ELPs), 10 silk-like polypeptides (SLPs), 11 extended recombinant polypeptide (XTEN) polymers, 12 and silk-elastin-like polypeptides (SELPs). 13 Alternatively, non-polymeric genetically engineered drug carriers with … WebNov 25, 2024 · Collagen elastin hybrid gels are a new representative of such materials as they employ elastin’s thermo switching behavior in the physiological temperature regime. ... respectively, which are in the acceptable ranges. The drug contents’ % yield and the %EE of folate-decorated NPs were 53 ± 1.8% and 59 ± 2%, respectively. The in vitro ...
Self-assembled particles of an elastin-like polymer as vehicles for ...
WebKaufmann & Weberskirch have investigated an elastin mimetic polypeptide-drug conjugate for targeted delivery of Doxorubicin and demonstrated that elastin mimetic polypeptide, GRDPSS(VPGVG VPGKG VPGVG VPGVG VPGEG VPGIG) 7 can be used as potential drug carriers for cancer chemotherapy. They used an efficient synthetic method for … WebElastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. Author links open overlay panel Pu Shi a, Suhaas Aluri a, Yi-An Lin b, ... With the new strategy, the drug associates tightly to the carrier and releases slowly, which may decrease toxicity and promote tumor accumulation via the ... project boundaries in project charter
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WebNov 30, 2024 · 1 Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People’s Hospital, Zhengzhou, China; 2 Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China; As the primary component … Moreover, elastin is reportedly involved in the development and progression of … Moreover, elastin is reportedly involved in the development and progression of … Loop is the open research network that increases the discoverability and impact … Education 1983-1985: Internal student attending the Institute of Biological … Loop is the open research network that increases the discoverability and impact … WebMar 13, 2024 · It is believed, however, to be due to a chronic biochemical imbalance between elastase (an enzyme capable of degrading elastin tissues, released by … WebNov 9, 2024 · The capacity for temperature-controlled self-assembly make elastin-like peptides well-suited for biomaterials applications (Almine et al., 2010) and drug delivery (Shi et al., 2013). Despite the biological importance of elastin and eighty years of study using a myriad of biophysical techniques ( Meyer and Ferri, 1937 ), neither the molecular ... project boundaries in project management