Cisplatin prehydration
WebFor cisplatin, hydration is always indicated and mannitol may be useful in selected settings. Furosemide is probably not generally useful. For carboplatin, hydration is … WebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the …
Cisplatin prehydration
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WebMannitol combined with hydration significantly prevented cisplatin-induced nephrotoxicity. Additionally, mannitol should be particularly considered among patients with cancer, treated with cisplatin > 80 mg/m2, or patients receiving concomitant radiation. WebCisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin-induced kidney injury has been reported. The MATE transporter is also involved in the excretion of ondansetron, but the effects of 5-HT 3 receptor antagonists used clinically for cisplatin-induced renal injury ...
WebAbstract The protective effect of methimazole, a commonly used antithyroid drug, on cisplatin-induced nephrotoxicity was studied. Eight dogs received 80 mg/m2 cisplatin i.v. without saline prehydration. WebPre-hydration Cisplatin dose < 50mg/m2: N/Saline in 1000ml over 1 hour. If another drug is being given in the regimen e.g. etoposide then this would be used as prehydration i.e. etoposide in 1000ml N/Saline. Cisplatin dose 50mg/m2 < 75mg/m2: N/Saline + KCl 20mmol/L in 1000mls over 1hr plus 100mls 10% mannitol (or equivalent)
http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebPreparation of cisplatin infusion: DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. Aluminium containing equipment should not be used …
http://www.bccancer.bc.ca/chemotherapy-protocols-site/Documents/Lung/LUAJPP_Protocol.pdf
Web75% (same prehydration as 75 mg/m² dose) less than 45 : Delay until creatinine clearance greater than 45 mL/min, then give 50% of CISplatin dose** **may reinstitute full dose CISplatin if renal function stable or improving after 2 more cycles . 3. Ototoxicity: Dose modifications required for CISplatin, Ototoxicity Dose (CISplatin) less than ... greek wrist tattoo ideasWebPreparation of cisplatin infusion: DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. Aluminium containing equipment should not be used for administration of cisplatin (see Section 6.2 Incompatibilities). c. Treatment: Following prehydration, administer the cisplatin infusion over 1-2 hours. flower falling apartWebJul 15, 2015 · Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many centers... flower fallingWebNational Center for Biotechnology Information greek writers and philosophersWebCisplatin can be detected in urine for weeks after a dose. III. DOSAGE AND ADMINISTRATION A) Administer as a short or long infusion but not IV push. B) Prehydration with 500 mL over 30 min - 2 hours, or 1000 mL NS over 2 - 4 hours. Compound the cisplatin in 500 mL NS and give over 1-2 hr. Post-hydration give 500- … greek wreath symbolWebDec 4, 2014 · As more than 90% of free cisplatin binds to plasma proteins within 4 h, hydration within that time after initiating treatment is a critical factor in reducing toxicity [ 8 ]. In addition, previous reports have demonstrated that cisplatin-induced Mg depletion may occur in some patients [ 9 ]. flower falling from handWebJun 23, 2024 · Depending on the protocol, 1 - 2 litres pre-hydration. The patient must have urinated a litre minimum before we proceed. Our cisplat goes in 250 mls usually giving us a final volume of 340 mls. We used to pass Mannitol concurrently but that's now been … greek wreath